Large-scale Vision-and-Language (V+L) pre-training for representation learning has proven to be effective in boosting various downstream V+L tasks. However, when it comes to the fashion domain, existing V+L methods are inadequate as they overlook the unique characteristics of both fashion V+L data and downstream tasks. In this work, we propose a novel fashion-focused V+L representation learning framework, dubbed as FashionViL. It contains two novel fashion-specific pre-training tasks designed particularly to exploit two intrinsic attributes with fashion V+L data. First, in contrast to other domains where a V+L datum contains only a single image-text pair, there could be multiple images in the fashion domain. We thus propose a Multi-View Contrastive Learning task for pulling closer the visual representation of one image to the compositional multimodal representation of another image+text. Second, fashion text (e.g., product description) often contains rich fine-grained concepts (attributes/noun phrases). To capitalize this, a Pseudo-Attributes Classification task is introduced to encourage the learned unimodal (visual/textual) representations of the same concept to be adjacent. Further, fashion V+L tasks uniquely include ones that do not conform to the common one-stream or two-stream architectures (e.g., text-guided image retrieval). We thus propose a flexible, versatile V+L model architecture consisting of a modality-agnostic Transformer so that it can be flexibly adapted to any downstream tasks. Extensive experiments show that our FashionViL achieves new state of the art across five downstream tasks.